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Updated: Jun 14, 2026

Hi-C: A Method to Study the Three-dimensional Architecture of Genomes.
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Published on: May 6, 2010

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哺乳动物细胞中同类染色体之间的广泛折叠变异性

Ibai Irastorza-Azcarate1, Alexander Kukalev2, Rieke Kempfer2,3,4

  • 1Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association (MDC), Berlin Institute for Medical Systems Biology (BIMSB), Epigenetic Regulation and Chromatin Architecture Group, 10115, Berlin, Germany. ibai.irastorzaazcarate@mdc-berlin.de.

Molecular systems biology
|May 6, 2025
PubMed
概括

遗传变异塑造了3D基因组结构,影响了基因表达. 这项研究使用基因组架构映射 (GAM) 揭示了单元型特异性染色质差异及其与等位基因特异性基因表达的联系,特别是通过Polycomb抑制调节的基因组基因.

关键词:
基特异性表达方式基因规则 基因规则基因组结构 基因组结构希斯通位点 (Histone Locus) 是一个位点.多重复合的多重复合.

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