开发和表征含有Quercetin-β-Cyclodextrin包容复合物的基托桑纳米颗粒,以提高溶解性,针对大脑,以及对的神经保护潜力
Priyabrata Pradhan1, Vineet Kumar Rai1, Jitu Halder1
1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan (Deemed to Be University), Kalinga Nagar, Bhubaneswar, 751030, Odisha, India.
AAPS PharmSciTech
|May 6, 2025
概括
装有氨酸-β-环氧化 (QNP) 的奇托桑纳米颗粒被开发用于改善氨酸.
科学领域:
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
- 药理学 药理学是指药理学的学科.
- 神经科学是一个神经科学.
背景情况:
- 奎尔素具有治疗潜力,但具有较差的溶解性,稳定性和生物可用性.
- 纳米粒子药物递送系统为克服这些局限性提供了一个有希望的方法.
- 素纳米颗粒是生物相容和生物降解的,使它们适合药物输送.
研究的目的:
- 开发和优化素纳米颗粒封装一个奎尔丁-β-环德克斯纳入复合体 (QNPs).
- 为了提高奎尔丁的溶解性,稳定性和生物可用性,以提高治疗疗效.
- 在模型中评估QNP的神经保护作用.
主要方法:
- 用于QNP配方的纳米沉方法,然后进行全面优化.
- 使用FTIR,DSC,X射线衍射和SEM进行物理化学表征.
- 在体外释放药物,小鼠的药理动力学研究,以及体内模型 (Pentylenetetrazole和Kainic酸诱导).
主要成果:
- 优化QNPs (批量B6) 显示稳定的合性质,成功包含氨酸和降低结晶性.
- 与自由氨酸相比,QNPs表现出受控的体外释放,增强的口服生物可用性和增加的大脑吸收.
- 在模型中,QNP显著降低了活动,增强了抗氧化酶水平,并保留了Na+/K+-ATPase活动.
结论:
- 优化的奇托桑纳米颗粒有效地封装了奎尔丁-β-环氧化,改善了其物理化学特性和生物可用性.
- 在模型中,QNP表现出显著的神经保护作用和抗活性.
- QNP代表了一种有前途的策略,用于增强素在等神经系统疾病中的治疗潜力.
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