肌肉休息对禁食血糖的年龄相关影响:对糖尿病前期风险的影响
Eshwar R Tammineni1, Lourdes Figueroa1, Michael Fill1
1Department of Physiology and Biophysics, Rush University Medical Center, Chicago, Illinois, USA.
肌肉细胞中的升高 (细胞质度) 与更高的禁食血糖有关. 这一发现表明一种潜在的风险因素发展2型糖尿病,特别是在老年人.
科学领域:
- 内分泌学 在内分泌学.
- 细胞生理学 细胞生理学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 骨肌肉是葡萄糖吸收和恒温的关键.
- 恶性高温症易感 (MHS) 个体具有较高的静止细胞质 ([Ca2+]细胞) 和高血糖的发病率.
- 升高的[Ca2+]细胞和空腹血糖 (FBS) 之间的联系需要进行调查.
研究的目的:
- 调查休息[Ca2+]细胞和FBS水平升高之间的关联.
- 分析[Ca2+]细胞对FBS的影响,考虑年龄,性别和MH状态.
- 根据[Ca2+]细胞和年龄来评估糖尿病前期风险.
主要方法:
- 来自MHS和对照对象的肌肉管从肌肉活检中培养出来.
- 测量了休息[Ca2+]细胞.
- 相关性,比较和分层分析 (热图,3D图) 用于评估FBS,[Ca2+]细胞和年龄之间的关系.
主要成果:
- 在MHS神经管中,休息[Ca2+]细胞的数量明显高于对照组.
- 在MHS受试者和整体队列中,[Ca2+]细胞与FBS正相关.
- 糖尿病前患者在[Ca2+]细胞和FBS之间显示出强烈的相关性. 40岁以上的[Ca2+]细胞数>150nM的受试者患糖尿病前期风险较高,年龄在这个群体中显著影响FBS.
结论:
- 骨肌中静止[Ca2+]细胞的升高与高血糖症的风险增加有关.
- 这种情况可能会导致2型糖尿病的发展.
- 年龄加剧了高[Ca2+]细胞对FBS的影响.
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