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Updated: May 23, 2025

Isolation of Translating Ribosomes Containing Peptidyl-tRNAs for Functional and Structural Analyses
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Published on: February 25, 2011

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5'-tRNAHisGUG片段:一种首选的内源TLR7配体,具有逆序激活洞察力

Kiran Bharat Lokhande1, Ashutosh Singh2, Rajan Vyas2

  • 1Department of Life Sciences, School of Natural Science, Shiv Nadar Institution of Eminence Deemed to Be University, Greater Noida, India; Computational Biophysics and CADD Group, Computational and Mathematical Biology Center, Translational Health Science and Technology Institute, Faridabad, India.

Biophysical journal
|May 7, 2025
PubMed
概括

自然存在的tRNA片段,5'-HisGUG和5'-ValCAC/AAC是强大的托尔类受体7 (TLR7) 激活剂. 这些分子表现出强大的结合和形状灵活性,为治疗用途提供比合成TLR7激动剂更安全的替代品.

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