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Updated: May 9, 2025

Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time
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Utilizing Time-Resolved Protein-Induced Fluorescence Enhancement to Identify Stable Local Conformations One α-Synuclein Monomer at a Time

Published on: May 30, 2021

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RNA对α-synuclein纤维的超分子结构的影响

Antonia Intze1, Maria Eleonora Temperini2, Jakob Rupert3

  • 1Center for Life Nano- & Neuro-science, Istituto Italiano di Tecnologia (IIT), Viale Regina Elena 295, 00161, Rome, Italy; Department of Biochemical Sciences "Alessandro Rossi Fanelli", Sapienza University of Rome, Piazzale Aldo Moro 5, 00185, Rome, Italy.

Biophysical journal
|May 7, 2025
PubMed
概括

这项研究揭示了RNA如何影响α-synuclein蛋白质聚合物. RNA增强了结构秩序,并减少了这些粉样聚合物的多态性,影响了它们的分子架构.

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