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Updated: May 9, 2025

Murine Drinking Models in the Development of Pharmacotherapies for Alcoholism: Drinking in the Dark and Two-bottle Choice
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问题性酒精使用与各种精神疾病之间的关系:一项基于基因的研究

Yeeun Ahn1, Jaehyun Kim1, Kyeongmin Jung1

  • 1Department of Digital Health (Ahn, K. Jung, J.Y. Jung, Park, Jaeyoung Kim, H. Kim, Jo, Hong, Won) and Department of Health Sciences and Technology (Lee), Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, Samsung Medical Center, Seoul, South Korea; Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, South Korea (Ahn, K. Jung, Park, Jaeyoung Kim, Myung); Department of Clinical Medical Sciences (Jaehyun Kim) and Department of Psychiatry (Eom, Myung), Seoul National University College of Medicine, Seoul, South Korea; Department of Medicine, Central Force for National Defense, Republic of Korea Army Personnel Command, Yongin, South Korea (Jaehyun Kim); Department of Neuropsychiatry, Seoul National University Hospital, Seoul, South Korea (Jaehyun Kim); Department of Psychiatry (J.Y. Jung) and Samsung Genome Institute (Won), Sungkyunkwan University School of Medicine, Samsung Medical Center, Seoul, South Korea; Norwegian Center for Mental Disorders Research, Institute of Clinical Medicine, University of Oslo, Oslo (O'Connell, Andreassen); Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway (O'Connell, Andreassen).

The American journal of psychiatry
|May 7, 2025
PubMed
概括

这项研究揭示了问题性酒精使用 (PAU) 与抑郁症和精神分裂症等精神疾病之间的显著遗传重叠. 关键基因TTC12和ANKK1被确定为这些并发病的潜在因果因素.

关键词:
常见的遗传变异 常见的遗传变异抑郁症 抑郁症 抑郁症 抑郁症遗传学 / 基因组学类型的人类.有问题的酒精使用 饮酒问题精神分裂症谱系和其他精神病障碍

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