营养状况和并发症是与抗结核治疗期间死亡率相关的重要因素
Oh Beom Kwon1, Hyung Woo Kim2, Ju Sang Kim2
1Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, Chuncheon, Korea.
营养不良和多种并发症显著增加了接受结核病治疗的患者的死亡风险. 识别这些因素对于改善患者的治疗结果和打击结核病至关重要.
科学领域:
- 肺部医学 肺部医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 根除工作面临的挑战是,韩国老年,并发病和营养不良个体的死亡率增加.
- 肺结核 (TB) 在治疗期间的死亡率是一个重大的公共卫生问题,特别是在弱势群体中.
研究的目的:
- 为了确定与肺结核接受抗结核治疗的患者的死亡率相关的因素.
- 研究营养状况和并发症对结核病治疗结果的影响.
主要方法:
- 一项用韩国多中心前性观察队列数据进行的病例对照研究.
- 分析了1,119名患有利芬素敏感性肺结核的患者,将完成治疗的患者 (生存组) 与死亡的患者 (死亡组) 进行比较.
- 使用单变量和多变量逻辑回归分析来确定结核病死亡率的预测因素.
主要成果:
- 该研究包括799名患者在生存组和59名患者在死亡组.
- 年龄,正面涂抹结果,令人担忧的症状,营养风险得分,查尔森并发症指数得分和初始治疗方案等因素在不变分析中具有重要意义.
- 在多变量分析中,营养风险评分 (aOR,2.44) 和查尔森并发症指数评分 (aOR,1.62) 独立与死亡率相关.
结论:
- 基线营养状况和并发病的存在是影响肺结核患者死亡率的关键因素.
- 这些发现凸显了评估和管理营养和并发性疾病的重要性,以改善结核病治疗结果.
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