结肠镜检查中的年龄和性别腺瘤检测率和查年龄的优化:回顾性分析
Burak Sakar1, Osman Zekai Oner1, Ali Celik1
1Department of General Surgery, Antalya Training and Research Hospital, University of Health Sciences, Antalya, Türkiye.
概括
结肠直肠癌查可能需要早些时候开始,特别是对于男性来说. 从45岁开始,腺瘤检测率显著增加,这表明需要重新评估当前的查指南.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 预防医学 预防医学
背景情况:
- 目前的结肠直肠癌 (CRC) 查指南在全球范围内各不相同.
- 开始CRC查的最佳年龄仍然是争论的主题.
- 了解不同人口群体的腺瘤检测率 (ADR) 对于改进指南至关重要.
研究的目的:
- 评估40-54岁的平均风险个体的腺瘤检测率 (ADR).
- 为了比较不同年龄层 (40-44,45-49,50-54) 和性别的不良反应.
- 为了告知国家CRC查指南的潜在修订.
主要方法:
- 对1216名接受结肠镜检查的患者进行了回顾性观察研究.
- 患者分为三个年龄组:40-44岁,45-49岁和50-54岁.
- 排除标准包括先前的多角切除术,家族CRC病史,不完整的结肠镜检查或不充分的肠道准备 (波士顿肠道准备量表得分<6).
主要成果:
- 总体ADR为20.8%,晚期瘤检测率 (ADNR) 为2.6%.
- 副作用显著增加,从7.6% (40-44岁) 增加到15.8% (45-49岁;P=.032).
- 与女性相比,男性的ADR (30.2%) 和DNAR (3.7%) 显著更高 (分别为13.1%和1.8%;P<.001和P=.048).
结论:
- 腺瘤检测率从45岁起显著增加,支持早期启动CRC查.
- 对ADR和ADNR的性别特异性表明需要量身定制的查策略.
- 建议进行进一步的前性多中心研究来验证这些发现.
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