为改善药物输送,开发和描述含有奎胺的基于微针的皮肤贴片,以改善药物输送
Maryam Itbar1, Muhammad Imran Khan1, Muhammad Furqan Akhtar1
1Riphah Institute of Pharmaceutical Sciences, Riphah International University, 54000, Lahore, Pakistan.
The Journal of pharmacy and pharmacology
|May 7, 2025
概括
这项研究开发了含奎氨酸的微针 (MNS) 补丁,用于增强通过皮肤递送药物. 优化的MNS贴片显示出显著的药物释放,显示出改善抗精神病治疗的前景.
科学领域:
- 制药科学 制药科学
- 生物材料工程 生物材料工程
- 药物输送系统 药物输送系统
背景情况:
- 通过皮肤递送的药物提供优势,比口服的 quetiapine 等抗精神病药物.
- 基于微针的系统提供了一种新的方法来克服皮肤屏障的局限性,以改善药物透.
研究的目的:
- 准备和表征含有奎胺的基于微针的通过皮肤贴片 (MNS).
- 评估MNS贴片的潜力,以增强通过皮肤递送奎胺.
主要方法:
- 八个MNS贴片 (MNS1-MNS8) 的制造,使用不同度的酸和碳甲基纤维素通过溶剂造.
- 针对MNS贴片的物理特性 (厚度,折叠耐久性),药物含量,形态 (SEM) 和通过Wistar老鼠皮肤的ex-vivo透的特征.
主要成果:
- 里埃变换红外光谱法 (FTIR) 证实了药物辅助剂的兼容性.
- 优化的MNS贴片表现出合适的物理特征,SEM显示了尖的针形态.
- 活体透研究表明,在48小时后,MNS1的高累积药物释放率为84.34%.
结论:
- 含有奎胺的MNS贴片是一种有前途的配方,可以改善通过皮肤递送药物.
- 开发的MNS技术为增强抗精神病药物管理提供了可行的替代方案.
- 需要进一步的体外研究来证实这种透皮系统的疗效和安全性.
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