完整脊髓损伤的儿科患者的拓结构和模块相互作用的改变:一个功能性大脑网络研究
Yu Wang1,2, Ling Wang3, Beining Yang1,2
1Department of Radiology and Nuclear medicine, Xuanwu Hospital, Capital Medical University, Beijing, China.
Journal of neurotrauma
|May 7, 2025
概括
儿科创伤性完全脊髓损伤 (CSCI) 改变大脑网络,特别是影响情绪和视觉功能. 儿科CSCI患者的网络变化可能会影响精神认知健康和运动功能的恢复.
科学领域:
- 神经科学是一个神经科学.
- 医疗成像医学成像
- 儿科神经学 儿科神经学
背景情况:
- 创伤性完全脊髓损伤 (CSCI) 在儿科患者中导致显著的感觉运动缺陷和神经心理问题,如焦虑和抑郁.
- 在患有CSCI的儿童中,大脑功能网络组织和模块化相互作用的具体变化尚未得到充分理解.
研究的目的:
- 研究与健康对照组相比,CSCI儿科患者全脑功能网络拓和模块化组织的变化.
- 确定潜在的神经成像生物标志物,以评估儿科CSCI中的运动功能恢复.
主要方法:
- 休息状态功能性MRI对34名儿科CSCI患者和36名健康对照 (6-12岁) 进行.
- 使用自动化解剖标记 (AAL 90) 地图的图形理论分析应用于静止状态的功能性MRI数据,以评估节点,全球和模块级的网络拓.
- 进行了组间比较和部分相关性分析,以确定显著的差异和关系.
主要成果:
- 儿科CSCI患者的节点指标下降,特别是在皮下网络 (SN),以及核心节点分布的改变,在默认模式网络 (DMN) 中有新的核心节点.
- 患者表现出改变的模块相互作用:DMN内部和DMN注意力网络 (AN) 连接性增加,但DMN-SN,DMN视觉网络 (VN) 和AN-SN连接性减少.
- 在CSCI患者中观察到较低的模块化,左极的参与系数与运动分数正相关.
结论:
- 儿科CSCI导致大脑功能网络组织和模块化的显著改变,特别影响情绪认知和视觉处理区域.
- 这些网络变化凸显了解决儿科CSCI患者心理认知健康问题的必要性.
- 鉴定的网络变化和与运动功能的相关性表明神经康复策略的潜在目标,包括视觉反干预.
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