COVID-19对帕金森病的长期结果的影响
Roham Hadidchi1, Yousef Al-Ani1, Hannah Piskun1
1Department of Radiology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York, USA.
European journal of neurology
|May 7, 2025
概括
COVID-19感染增加了帕金森病 (PD) 患者的长期风险,包括死亡率和心血管事件. 提高临床意识和随访对于COVID-19后的PD患者至关重要.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 帕金森病 (PD) 患者患重症急性COVID-19的风险更高.
- 在PD患者中COVID-19感染后的长期结果尚不清楚.
研究的目的:
- 在布朗克斯市中心的帕金森病患者群体中,研究COVID-19感染后长达3.5年的长期临床结果.
- 为了比较PD患者与没有COVID-19病史的PD患者之间的结果.
主要方法:
- 从2016年1月到2023年7月,对3512名帕金森病患者进行了回顾性研究.
- 在COVID-19阳性和阴性PD患者之间比较包括死亡率,主要不良心血管事件 (MACE) 和神经症状在内的结果.
- 针对竞争风险计算的调整危险比率 (aHR),包括莱沃多巴处方的变化.
主要成果:
- 患有COVID-19的PD患者有更高的并发病患病率.
- 在PD患者中,COVID-19与死亡率 (aHR=1.58) 和MACE (aHR=1.57) 的风险增加有关.
- 在COVID-19后的PD患者中观察到呼吸障碍,疲劳和跌倒的风险增加,利沃多巴剂量调整率更高.
结论:
- COVID-19感染与帕金森病患者长期不良结果的风险更高有关.
- 建议对在COVID-19中幸存下来的PD患者进行密切的临床跟踪和提高意识.
- 需要改进后COVID护理策略,以缓解疾病进展并提高PD患者的生活质量.
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