减少舌头空间/舌头体积比作为口腔舌头状细胞癌的危险因素 - - 一项探索性研究
Mahija Janardhanan1, C J Sandya2, Manu Raj3
1Department of Oral & Maxillofacial Pathology, Amrita Vishwa Vidyapeetham, Amrita School of Dentistry, Kochi, Kerala, India.
概括
较低的舌头空间-舌头体积比率是口腔舌头状细胞癌的重要危险因素,特别是在年轻人中. 这一发现突出了早期检测和预防策略的潜在新途径.
科学领域:
- 口腔瘤学 在口腔瘤学
- 放射学 放射学是一门学科.
- 头部和部手术的手术.
背景情况:
- 没有传统风险因素的年轻成年人的舌头癌症越来越令人担忧.
- 研究诸如舌头空间-舌头体积比率之类的解剖学变异对于理解病因学至关重要.
研究的目的:
- 为了确定舌头空间和舌头体积比较低是否是口腔舌头状细胞癌的危险因素.
- 为这种潜在的风险因素建立一个可量化的衡量标准.
主要方法:
- 一项病例控制研究,涉及50名口腔舌状细胞癌患者和50名健康对照.
- 磁共振成像 (MRI) 用于测量舌头空间和舌头体积.
- 统计分析,包括独立的t测试和接收器操作特征 (ROC) 曲线,用于确定舌头空间/舌头体积 (TS/TV) 的比率及其意义.
主要成果:
- 与对照组相比,在舌头癌症患者中观察到较低的统计学意义上的平均TS/TV比率 (p=0.009).
- 在ROC曲线分析中,发现舌头癌症发展的TS/TV比率截止值为1.259.
- 低TS/TV比率的个体对于恶性转变的几率比率为2.6.
结论:
- 降低TS/TV比率与口腔舌状细胞癌显著相关.
- 这种解剖学特征反映了舌头空间减少或舌头体积增加,可能会使个体易患舌头癌症.
- 这些发现表明,TS/TV比率是评估舌头癌症风险的潜在生物标志物.
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