胃癌诊断后心血管死亡率的风险分析:一项基于人口的大型研究
Qiang Zhao1, Qiaohong Zhou2, Jiayue Dong3
1Department of Cardiology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, Zhejiang, China.
Frontiers in cardiovascular medicine
|May 7, 2025
概括
心血管疾病 (CVD) 死亡率在胃癌 (GC) 幸存者中正在增加. 这项研究确定了年龄,癌症阶段,手术和放射治疗是GC患者心血管疾病死亡的关键预测因素,为长期护理策略提供了信息.
科学领域:
- 心脏瘤学 - 心脏瘤学
- 癌症流行病学癌症流行病学
- 公共卫生 公共卫生
背景情况:
- 癌症幸存者面临着心血管死亡风险的增加.
- 胃癌 (GC) 幸存者是对心血管疾病 (CVD) 发展的关注人口.
- 了解GC患者的CVD特异性死亡率趋势和风险因素对于改善幸存者护理至关重要.
研究的目的:
- 研究胃癌患者心血管死亡的动态趋势.
- 确定非转移性胃癌患者心血管疾病特异性死亡率的预后风险因素.
主要方法:
- 利用监测,流行病学和最终结果 (SEER) 数据库收集了29324名初级胃癌患者的数据.
- 根据年龄,性别,日历年和种族调整而计算的标准化死亡率 (SMR).
- 采用Fine-Gray的竞争风险模型来确定心血管死亡的预后因素.
主要成果:
- 心血管死亡发生在5.2%的局部/区域GC患者和0.9%的转移GC患者中.
- 针对心脏病特异性死亡率的标准化死亡率从20世纪70年代到2010年代持续增加.
- 心血管疾病特异性死亡率的关键预测因素包括老年 (>75岁),晚期T和N阶段,接受手术和放射治疗.
结论:
- 这项研究阐明了胃癌患者心血管死亡的演变趋势.
- 确定了心血管死亡率的显著预后预测因素,强调了综合性心脏瘤治疗的必要性.
- 开发了一种名谱来预测局部/区域胃癌患者心血管疾病特异性死亡风险,有助于量身定制的随访.
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