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用沙漠适应植物治疗多药耐药细菌诱导的败血症的治疗方法

Nesreen Safwat¹, Rana Elshimy², Soha O Hassanin³

¹Department of Microbiology and Immunology, Faculty of pharmacy, Modern University for Technology and Information, Cairo, Egypt.

Frontiers in cellular and infection microbiology

|May 7, 2025

概括

沙漠植物提取物Jasonia candicans在对抗多药耐药细菌方面表现有前途. 与阿米卡结合,它增强了抗生素的有效性,并减少了与败血症相关的组织损伤.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
民族植物学民族植物学

背景情况:

败血症是一种危及生命的疾病,通常是由多药耐药 (MDR) 细菌引起的.
传统的抗生素对MDR病原体越来越无效,需要新的治疗策略.

研究的目的:

研究适应沙漠的药用植物提取物作为常规抗生素治疗败血症的辅助剂的潜力.
评估选定植物提取物的抗微生物,抗炎和抗氧化特性.

主要方法:

对400名败血症患者的血液样本进行分析,以检测格拉姆阴性细菌分离物和抗菌素耐药性.
在体外评估植物提取物 (Jasonia candicans,Cistanche tubulosa,Moltkiopsis ciliata,Thymelea hirsuta) 的抗微生物,COX-1/COX-2抑制和抗氧化活性.
在体内评估组合治疗的有效性和安全性,使用小鼠的体病理学检查.

主要成果:

发现了MDR大肠杆菌和K.肺炎的高患病率.
杰索尼亚candicans提取物显示出强大的抗微生物,COX-1/COX-2抑制和抗氧化活性.
结合J.candicans提取物与阿米卡辛,显示出协同作用,恢复了耐药菌株的敏感性,并减少了小鼠的组织损伤.

结论:

杰索尼亚candicans提取物具有显著的潜力,作为一个补充治疗的MDR格兰氏阴性感染.
提取物的抗微生物,抗炎和抗氧化特性为改善败血症管理提供了有希望的途径.

关键词:

詹姆斯·坎迪卡纳斯 (J. Candicans) 是一个这就是阿米卡辛.具有格拉姆阴性.药用植物药用植物败血症患者的感染病例

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