视觉幻觉与莱维体痴呆症和阿尔茨海默病的认知表现之间的关联:一个横截面研究
Yaqi Yang1, Fan Yang1, Jinghuan Gan2
1Department of Neurology, Tianjin Huanhu Hospital, Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Journal of Alzheimer's disease reports
|May 7, 2025
概括
视觉幻觉 (VH) 在患有莱维体 (DLB) 的痴呆症中比阿尔茨海默病 (AD) 更常见. VH与认知能力下降相关,影响DLB中的注意力和AD中的定向.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 认知科学 认知科学
背景情况:
- 视觉幻觉 (VH) 是痴呆症中一个重要的神经精神症状.
- VH和认知衰退之间的关系尚未完全理解.
- 勒维体痴呆症 (DLB) 和阿尔茨海默病 (AD) 是常见的痴呆症形式,具有不同的临床特征.
研究的目的:
- 为了比较VH在DLB和AD患者中的临床特征.
- 研究VH与DLB和AD的认知功能之间的关联.
- 探索DLB和AD中受VH影响的认知领域的潜在差异.
主要方法:
- 对154名DLB和297名AD患者的门诊病历的回顾性分析 (2017年1月至2023年12月).
- 通过神经心理评估评估人口统计数据,认知功能和通过详细采访评估VH存在.
- 使用多重线性回归和调解分析进行统计分析,控制混变量.
主要成果:
- 与AD患者相比,VH患病率在DLB患者中明显高 (p < 0.01).
- 在DLB和AD中,VH存在与全球认知测试 (MMSE,MoCA) 的较低分数相关 (p < 0.01).
- 在DLB中,VH与注意力受损相关 (p=0.027);在AD中,VH与方向性恶化相关 (p=0.033). 注意力和导向部分调解了DLB和AD中的VH认知联系.
结论:
- 视觉幻觉可能独立地导致痴呆症的认知恶化.
- 在患有VH的DLB患者中,注意力缺陷突出,而在患有VH的AD患者中,定向缺陷更为明显.
- 对受VH影响的认知领域的影响差异可能有助于区分DLB和AD.
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