在患有帕金森病的患者中,有或没有可能的快速眼动睡眠行为障碍的性别特异性大脑形态和网络差异
Yang Liu1,2,3, Pengfei Zhang1,2,3, Hao Li1,2,3
1The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Frontiers in neurology
|May 7, 2025
概括
帕金森病 (PD) 中的性别特定的大脑变化在患有快速眼动睡眠行为障碍 (RBD) 的患者中更为明显. 与女性相比,男性PD-RBD患者的灰质体积较低,网络集成受损,影响认知表现.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 性别影响疾病的呈现,但在帕金森病 (PD) 中与快速眼动睡眠行为障碍 (RBD) 相关或不相关的性别特异性大脑形态尚不清楚.
- 研究PD小组中的性别特异性形态变化对于理解疾病异质性至关重要.
研究的目的:
- 调查PD患者中可能有RBD (PD-pRBD) 和没有RBD (PDnon-pRBD) 的脑形态模式的性别特异性差异.
主要方法:
- 利用来自帕金森病进展标记计划数据库的278名参与者的T1加权MRI数据 (PD-pRBD,PD-non-pRBD和健康对照).
- 使用计算解剖学工具箱 (CAT 12) 用于灰质体积 (GMV) 和皮质度量,构建个体级别的形态相似性网络.
- 使用图形理论方法分析网络拓性质.
主要成果:
- 在PD-pRBD中,男性的前额和部GMV比女性更低. 在PDnon-pRBD中,男性的前额缩指数 (GI) 比女性低.
- 与女性相比,男性PD-pRBD患者的网络信息整合 (全球碎形维度) 减少.
- 男性PD-pRBD患者在形态网络指标和认知表现 (HVLT-R记忆得分) 之间显示出显著的相关性.
结论:
- 在PD-pRBD患者中,与PD-pRBD患者相比,大脑形态的性别相关差异更明显.
- 这些发现强调了考虑性别作为PD-pRBD诊断和管理的一个因素的重要性.
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