甲状腺激素配置和病之间的相关性:改善全球结果 (KDIGO) 糖尿病病患者的风险类别
Kashif Abdullah1,2, Anjum Shahzad2,3, Seemab Javaid4
1Nephrology, Chelsea and Westminster Hospital NHS Foundation Trust, London, GBR.
Cureus
|May 7, 2025
概括
甲状腺功能障碍与糖尿病病 (DKD) 的恶化有关. 随着病风险的增加,甲状腺激素水平发生变化,与功能标志物相关联.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 内分泌学 在内分泌学.
- 内部医学 内部医学
背景情况:
- 甲状腺功能障碍在糖尿病病 (DKD) 中很普遍,可能会影响其进展.
- 调查甲状腺激素配置文件与DKD严重程度之间的联系对于患者管理至关重要.
研究的目的:
- 为了检查甲状腺激素水平 (FT3,FT4,TSH) 和病之间的关系:改善整体结果 (KDIGO) 在DKD患者的风险分层.
主要方法:
- 一项横截面研究分析了350名DKD患者,评估了甲状腺激素,eGFR,ACR,肌素,HbA1c和糖尿病持续时间.
- 患者被分为KDIGO风险类别.
主要成果:
- 甲状腺功能障碍的患病率随着KDIGO风险的增加而增加 (p=0.005).
- 自由三甲状腺素 (FT3) 和自由甲状腺素 (FT4) 水平下降,而甲状腺刺激激素 (TSH) 增加,导致KDIGO风险更高.
- FT3和FT4与eGFR,ACR和肌素有显著的相关性,表明晚期DKD中甲状腺功能发生改变.
结论:
- 甲状腺功能障碍与DKD严重程度密切相关.
- 甲状腺激素配置文件与关键的脏标记物相关,这表明它们在监测DKD进展和功能方面的潜在作用.
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