小肠细菌过度生长和肠道甲素过度生长在胃肠道恶性瘤
Aleksandra Mechlińska1, Katarzyna Frąckiewicz2, Katarzyna Gładyś-Cieszyńska3
1Department of Oncology and Radiotherapy, Medical University of Gdańsk and University Clinical Center, Gdańsk, Poland.
Contemporary oncology (Poznan, Poland)
|May 7, 2025
概括
小肠细菌过度生长 (SIBO) 和肠道甲素过度生长 (IMO) 在癌症患者中很常见,增加了营养不良的风险. 为了更好的诊断和针对这些胃肠道疾病的向治疗,需要更多的研究.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 微生物学 微生物学
背景情况:
- 细肠细菌过度生长 (SIBO) 涉及细肠中的细菌繁殖,而肠道甲素过度生长 (IMO) 涉及产生甲的古生物.
- 无论是SIBO还是IMO都会破坏胃肠道的运动,导致各种临床症状.
- SIBO与营养不良和营养物质吸收不良 (例如,维生素B12,脂溶性维生素) 有关,严重影响癌症患者的治疗结果.
研究的目的:
- 审查当前关于SIBO和IMO在胃肠道癌症方面的知识.
- 突出这些疾病在癌症患者中的患病率和临床意义.
- 识别当前研究中的差距,并建议未来的方向.
主要方法:
- 关于SIBO和IMO在胃肠癌中的当前研究的文献综述.
- 对一般癌症和癌症群体的流行数据的分析.
- 综合有关诊断挑战,营养影响和治疗方法的信息.
主要成果:
- 胃癌 (65%),结直肠癌 (65%) 和胰腺癌 (63.3%) 患者的SIBO患病率明显高于健康对照 (13.3%).
- SIBO/IMO的症状经常与其他疾病重叠,使诊断和治疗复杂化.
- 目前的知识受限于缺乏验证的诊断,基于证据的营养指南,以及对症状控制的关注.
结论:
- 在胃肠道癌症中,SIBO和IMO代表了显著的,未被认可的并发症,加剧了营养不良,影响了治疗结果.
- 对癌症患者的SIBO/IMO进行验证的诊断工具,向疗法和个性化的营养干预措施至关重要.
- 未来的研究应该专注于了解复发机制,并制定特定的治疗策略,而不仅仅是管理一般症状.
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