艾滋病毒感染者的氧化压力:多种补充来源是解决方案吗?
Esimebia Adjovi Amegashie1, Ruth Oyawole Sikeola1, Emmanuel Ayitey Tagoe2
1West African Center for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology University of Ghana Accra Greater Accra Region Ghana.
Health science reports
|May 7, 2025
概括
抗逆转录病毒疗法 (ART) 有助于控制人类免疫缺陷病毒 (HIV),但氧化应激症在艾滋病毒感染者 (PLWH) 中仍然存在. 抗氧化剂补充剂显示出改善PLWH健康结果的希望.
科学领域:
- 免疫学 免疫学 免疫学
- 生物化学 生物化学
- 公共卫生 公共卫生
背景情况:
- 抗逆转录病毒疗法 (ART) 已经将人类免疫缺陷病毒 (HIV) /艾滋病转化为可管理的慢性疾病.
- 尽管有ART,潜伏性艾滋病毒感染导致免疫功能障碍,炎症,氧化应激,DNA损伤和艾滋病毒感染者过早衰老 (PLWH).
- 氧化应激,标志着过度反应性氧物种,有助于线粒体DNA损伤,癌症和与年龄相关的疾病在PLWH.
研究的目的:
- 本综述综合了有关艾滋病毒感染者 (PLWH) 氧化应激现象的当前知识.
- 它旨在突出氧化应激对PLWH的影响,并探索潜在的治疗干预措施.
主要方法:
- 通过使用谷歌学者,Scopus,PubMed和Science Direct进行了系统的文献搜索.
- 包括在2013年1月至2023年12月期间发表的研究,遵守PRISMA指南.
- 总共有75项涉及人类参与者,细胞系和动物模型的研究分析了氧化应激水平.
主要成果:
- 在吸烟或滥用物质的HIV阳性个体中观察到氧化应激增加.
- 与短期使用相比,长期使用ART与较高的氧化蛋白产品和较低的抗氧化剂水平相关.
- 在临床前研究中,补充N-乙囊,和西利宾因表明细胞活力和抗氧化剂水平增加.
结论:
- 抗氧化剂干预,特别是天然和合成产品,有可能改善PLWH的福祉.
- 需要进一步的研究来验证这些研究结果在人类参与者.
- 针对氧化应激可能是提高艾滋病毒感染者的健康结果的关键策略.
相关概念视频
01:29Pulmonary Tuberculosis I
208
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
208
01:26Aging
26
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
26
01:46Electron Transport Chain: Complex I and II
9.6K
The mitochondrial electron transport chain (ETC) is the main energy generation system in the eukaryotic cells. However, mitochondria also produce cytotoxic reactive oxygen species (ROS) due to the large electron flow during oxidative phosphorylation. While Complex I is one of the primary sources of superoxide radicals, ROS production by Complex II is uncommon and may only be observed in cancer cells with mutated complexes.
ROS generation is regulated and maintained at moderate levels necessary...
ROS generation is regulated and maintained at moderate levels necessary...
9.6K
01:10Retrovirus Life Cycles
45.4K
Retroviruses have a single-stranded RNA genome that undergoes a special form of replication. Once the retrovirus has entered the host cell, an enzyme called reverse transcriptase synthesizes double-stranded DNA from the retroviral RNA genome. This DNA copy of the genome is then integrated into the host’s genome inside the nucleus via an enzyme called integrase. Consequently, the retroviral genome is transcribed into RNA whenever the host’s genome is transcribed, allowing the...
45.4K