可食用大麻素会影响雌性大鼠的食结构和食物冲动性
Magen N Lord1, Mai O Spaulding1, Jessica R Hoffman2
1Department of Nutritional Sciences, University of Georgia, Athens, GA 30606, USA.
iScience
|May 7, 2025
概括
可食用大麻素通过增加食大小而不是食频率来增加食物摄入量. 这种加剧的饮食行为与冲动性增加有关,而不是动机或焦虑的改变,这表明自我控制能力下降.
科学领域:
- 神经科学是一个神经科学.
- 行为药理学行为药理学
- 内分泌学 在内分泌学.
背景情况:
- 众所周知,大麻素受体激动剂可以刺激食欲.
- 导致大麻素诱导饮食的精确行为机制,特别是女性,仍然不完全理解.
- 食用消费是人类常见的吸收大麻素的途径.
研究的目的:
- 研究可食用大麻素给药对雌性大鼠的食物摄入量和相关行为的影响.
- 阐明与大麻素诱导的过相关的行为机制,包括饮食模式,冲动性,动机和焦虑.
主要方法:
- 给雌性大鼠以可食用形式的双重大麻素受体激活剂 (CP55940) 的使用.
- 测量标准食摄入量,食大小和食数量.
- 评估冲动反应和对糖的动机.
- 对类似焦虑的行为进行评估.
主要成果:
- 可食用CP55940急剧增加了标准食摄入量,主要是通过增加食大小,而食数量没有显著改变.
- 可食用CP55940的过剂量增强了对糖糖的冲动反应.
- 在测试剂量时,没有观察到对糖的动机或类似焦虑行为的显著变化.
结论:
- 可食用大麻素的管理延迟了和,导致通过大餐增加食物摄入量.
- 大麻素诱导的过与增加的冲动性饮食行为有关,可能是由于抑制控制的减少.
- 这些影响独立于食物动机或焦虑水平的变化而发生.
更多相关视频
05:15Author Spotlight: Accessible M&M-Based Mouse Model for Investigating Binge Eating Disorder - Insights into Eating Behaviors, Anxiety, and Neural Mechanisms
Published on: January 10, 2025
632
11:16A Novel Procedure for Evaluating the Reinforcing Properties of Tastants in Laboratory Rats: Operant Intraoral Self-administration
Published on: February 6, 2014
12.6K
相关概念视频
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
187
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
187
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
134
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
134