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通过锁定分子内共价键来改善NIR-II光体的光亮度:一个理论观点
Lingling Dong1, Yuying Du1, Meina Zhang1
1International School for Optoelectronic Engineering, School of Chemistry and Chemical Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China. weihu@qlu.edu.cn.
Physical chemistry chemical physics : PCCP
|May 7, 2025
概括
研究人员开发了一种新策略,以提高生物医学成像中的第二近红外 (NIR-II) 光体的亮度. 通过将分子结构与共价键锁定,他们显著提高了光量子产量和亮度,以更好地可视化深层组织.
科学领域:
- 生物医学光学 生物医学光学
- 材料科学 材料科学 材料科学
- 有机化学 有机化学
背景情况:
- 第二次近红外 (NIR-II) 光成像为生物医学应用提供深层组织透和高分辨率.
- 目前的NIR-II光体通常由于低光量子产量而显示的亮度不足.
- 提高光的亮度对于提高NIR-II成像灵敏度和效用至关重要.
研究的目的:
- 为了研究在捐赠者-接受者-捐赠者NIR-II光体中光亮度增强的机制.
- 探索分子内共价键锁定对光光物理性质的影响.
- 开发用于生物医学应用的高性能NIR-II光剂.
主要方法:
- 合成和特征化了具有和没有分子内共价键 (例如,TQ-1和TQ-4) 的供体-受体-供体光体.
- 研究了结构修改对光吸收和光发射光谱的影响.
- 分析了分子结构,电子转换和发光效率之间的关系,重点关注非辐射衰变途径.
主要成果:
- 在受体段内锁定分子内共价键,通过促进结构放松,降低了发光效率.
- 锁定终端基增加了附带激发能量,降低了电子振动合,减少了非辐射衰变.
- 具有锁定终端基的TQ-4光体显示出最佳的光量子产量和亮度与NIR-II发射.
结论:
- 内分子共价键锁定是一种可行的策略,用于构建高效的NIR-II光体.
- 基于控制结构放松和电子合的合理设计原则可以产生改进的光体.
- 开发的TQ-4光体显示出先进的生物医学成像应用的巨大潜力,需要高亮度和深层组织透.
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