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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...

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Fabrication of Polymer Microspheres for Optical Resonator and Laser Applications
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智能聚合物微球:制备,微结构,刺激反应性质和应用.

Tao Guo1, Lan Luo1, Linlin Wang1

  • 1Centre for Composite Materials and Structures, Harbin Institute of Technology (HIT), No. 2 Yikuang Street, Harbin 150080, People's Republic of China.

ACS nano
|May 7, 2025
PubMed
概括

智能聚合物微球 (SPM) 是多功能材料,可根据温度或pH等刺激而发生变化. 本综述涵盖了它们的准备,多样化的响应行为,以及在药物输送和环境监测中的应用.

关键词:
应用程序 应用程序生物刺激生物刺激化学刺激是一种化学刺激.微球是微球的组成部分.微观结构的微观结构物理刺激 物理刺激准备 准备 准备智能材料是一种智能材料.刺激-反应性属性 刺激-反应性属性

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科学领域:

  • 材料科学 材料科学 材料科学
  • 聚合物化学 聚合物化学
  • 纳米技术纳米技术

背景情况:

  • 智能聚合物微球 (SPM) 是具有可调节结构的刺激响应材料.
  • 它们对外部刺激 (温度,pH值,光线,磁场) 的反应性使得它们能够有多种应用.

研究的目的:

  • 为SPM提供最近制备方法的全面审查.
  • 检查SPM的各种刺激反应行为.
  • 探索SPM在关键技术领域的应用.

主要方法:

  • 详细审查物理制备方法:乳化-溶剂蒸发,微流体,静电喷雾.
  • 详细审查化学制备方法:乳液和沉聚合.
  • 检查不同的刺激反应行为 (温度,pH值,光,磁性).

主要成果:

  • 可以使用各种物理和化学方法制备SPM.
  • SPM对外部刺激表现出多样化的响应行为.
  • 在药物输送,组织工程和环境监测方面,SPM有着重要的应用.

结论:

  • 由于其刺激反应性质,SPM是具有广泛应用性的先进材料.
  • 对准备和响应能力的持续研究将推动未来的技术进步.
  • 应对技术挑战对于SPM的未来发展至关重要.