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Updated: May 21, 2025

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离子-DNA相互作用作为 uracil DNA 糖酶活性的一个关键决定因素

Sharon N Greenwood1,2, Alexis N Dispensa1,2, Matthew Wang1,2

  • 1Department of Molecular Biology, Rowan-Virtua School of Osteopathic Medicine, Rowan University, Stratford, New Jersey 08084, United States.

Biochemistry
|May 7, 2025
PubMed
概括

离子 (Mg2+) 以双相的方式影响DNA糖酶 (UNG2) 活性,在低度时刺激它,在高度时抑制它. 这种离子-DNA相互作用对于 uracil 基切除修复至关重要.

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