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Updated: May 12, 2025

Personalized Peptide Arrays for Detection of HLA Alloantibodies in Organ Transplantation
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新的HLA-A*26:254等位基因从厄瓜多尔的一名混血儿中鉴定出来

Malgorzata Kosierb1, Veronika Byers1, Claire Zheng1

  • 1The Mount Sinai Hospital, Histocompatibility and Immunology Laboratory, New York, New York, USA.

HLA
|May 7, 2025
PubMed
概括

一个新的人类白细胞抗原 (HLA) 基因,HLA-A*26:254,在来自厄瓜多尔的健康个体中被发现. 这一发现有助于了解南美人口中的HLA多样性.

关键词:
HLA-A*26:254 这是一个很好的例子.这是一个混血儿混血儿.下一代测序 (NGS) 类型编码

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Pleiotropy01:33

Pleiotropy

Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
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