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色脂肪细胞通过BMP4信号促进三阴性乳腺癌细胞迁移和恶性病变

Ying-Fang Chen¹, Chung-Lin Jiang¹, Chi-Ling Tan¹

¹Department of Biochemical Science and Technology, National Taiwan University, Taipei, Taiwan.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

|May 7, 2025

概括

色脂肪细胞是一种脂肪细胞,通过分泌骨形态遗传蛋白4 (BMP4) 来促进三阴性乳腺癌 (TNBC) 的进展. 准BMP4信号可能为TNBC提供新的治疗策略.

科学领域:

细胞生物学细胞生物学
在瘤学瘤学.
内分泌学在内分泌学.

背景情况:

脂肪细胞与乳腺癌的相互作用会影响癌症的进展.
乳腺脂肪包括白色和棕色的脂肪细胞,后者在癌症中的作用尚不清楚.
三阴性乳腺癌 (TNBC) 是乳腺癌的一个特别激进的形式.

研究的目的:

研究色 (UCP1^高) 和白色 (UCP1^低) 脂肪细胞在TNBC进展中的作用.
阐明脂肪细胞影响TNBC细胞迁移和入侵的机制.
基于脂肪细胞信号传递,探索TNBC的潜在治疗点.

主要方法:

差异化的人类脂肪衍生的介酶干细胞成白色和色脂肪细胞.
用来自这些脂肪细胞的条件介质处理了TNBC MDA-MB-231细胞.
采用了从暴露于寒冷和室温的小鼠中获得的初级脂肪细胞的ex vivo模型.
测量细胞迁移,入侵和基因表达.
研究了使用诺金抑制剂信号传递骨形态蛋白4 (BMP4) 的作用.

主要成果:

与白色脂肪细胞条件介质 (hWCM) 相比,色脂肪细胞条件介质 (hBCM) 显著增加了MDA-MB-231细胞迁移和入侵.
色脂肪细胞分泌了更高水平的BMP4,从而增强了TNBC细胞迁移.
与Noggin一起抑制BMP信号传递减少了hBCM诱导的TNBC细胞迁移和恶性瘤.
与UCP1^高脂肪细胞共同培养增加了MDA-MB-231细胞迁移和改变了上皮细胞-介质细胞过渡基因表达.

结论:

UCP1高色脂肪细胞促进TNBC的进展,特别是迁移和入侵.
色脂肪细胞的BMP4信号传递是调解色脂肪细胞的前瘤效应的关键机制.
针对BMP4信号提供了一个潜在的TNBC治疗策略.

关键词:

在 BMP4 中,您可以使用 BMP4.美国TNBC电视台黄色的脂肪细胞乳腺癌乳腺癌乳腺癌瘤微环境是一个微环境.

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