为良性甲状腺疾病进行甲状腺切除术后永久性甲状腺缺血症患者的生活质量:基于人群的长期随访研究
Matilda Annebäck1, Sofia Wachtmeister1, Jakob Hedberg1
1Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
BJS open
|May 7, 2025
概括
在全甲状腺切除术后的长期随访显示,永久性甲状腺功能低下症患者的健康相关生活质量没有差异. 这些发现挑战了先前的研究,并表明需要进一步的研究.
科学领域:
- 内分泌学 在内分泌学.
- 甲状腺手术 甲状腺手术
- 生活质量研究 研究 生命质量研究
背景情况:
- 之前的研究表明,永久性甲状腺功能低下会对甲状腺切除术后的生活质量产生负面影响.
- 有关短期随访期,选择偏差和先前研究中的混因素存在担忧.
- 本研究通过使用严格的定义和长期数据来解决这些局限性.
研究的目的:
- 在全甲状腺切除术后,研究与健康相关的生活质量 (HRQoL) 在患有和没有永久性甲状腺功能低下症的患者中.
- 为了提供一个长期的视角,永久性下甲状腺功能障碍的影响.
- 批判性地评估甲状腺切除术后HRQoL的先前发现.
主要方法:
- 在瑞典,在2005-2015年间鉴定出了一组为良性甲状腺疾病进行全甲状腺切除术的患者.
- 患者被邀请参加2021年,资格评估.
- 与健康相关的生活质量使用36项简短形式健康调查版本2 (SF-36) 进行了测量.
主要成果:
- 总共有716名患者 (48.3%) 完成了SF-36问卷,平均随访时间为10.9年.
- 患有永久性甲状腺功能低下症的患者在基线较年轻,但其他方面具有与对照组相似的特征.
- 在所有领域 (P > 0.05) 中,在患有和没有永久性甲状腺功能下降症的患者之间,没有观察到与健康相关的生活质量的显著差异.
结论:
- 长期随访显示,在甲状腺切除术后患有和没有永久性甲状腺功能低下症的患者之间,与健康相关的生活质量没有差异.
- 这些发现与之前的研究形成鲜明对比,并强调需要进行强有力的长期研究.
- 永久性甲状腺功能低下症对生活质量的影响需要进一步的全面调查.
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