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Updated: May 12, 2025

A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
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协同作用的HDAC4/8抑制通过pAKT/RUNX2路径调制使骨肉瘤对多克索鲁比敏感

Anuja Gajanan Magar1,2, Vivek Kumar Morya1,2, Young-Ho Koh3

  • 1School of Medicine, Hallym University, Chuncheon-si 24252, Republic of Korea.

International journal of molecular sciences
|May 7, 2025
PubMed
概括

将多克索鲁与双脱乙酶 (HDAC) 抑制剂tasquinimod和PCI-34051结合起来,通过增加亡并减少细胞迁移和化学抵抗,可以增强骨髓瘤治疗.

关键词:
这是一种HDAC抑制剂.这是一种抗癌药物.灭症 (apoptosis) 是一种死亡的过程.组合疗法治疗组合治疗.德克索鲁比辛 (doxorubicin) 是一种药物.骨质肉瘤是骨质肉瘤的一种疾病.

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