相关实验视频

Updated: May 12, 2025

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

海湾战争的疾病在压力条件下诱导了性别特异的转录差异

Joshua Frank¹, Lily Tehrani², Jackson Gamer²

¹Institute for Neuro-Immune Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, FL 33328, USA.

International journal of molecular sciences

|May 7, 2025

概括

海湾战争疾病 (GWI) 显示了在压力下性别特异性基因表达变化. 识别这些转录基因标记物可能会导致更好的生物标记物和治疗GWI退伍军人.

科学领域:

基因组学就是基因组学.
免疫学免疫学免疫学
退伍军人的健康退伍军人的健康

背景情况:

海湾战争疾病 (GWI) 是一种复杂的多症状疾病,影响了1990-1991年波斯湾战争的退伍军人.
目前对GWI因果关系,诊断和治疗的理解仍然有限.
以前的研究表明,免疫失调和神经症状是GWI的关键特征.

研究的目的:

为了研究与健康对照人群相比,GWI的退伍军人中与压力相关的,性别特异的转录组变化.
识别与GWI病理生理学相关的潜在RNA测序生物标志物.
探索性特异性免疫反应和GWI中的信号通路.

主要方法:

对来自GWI受试者和对照者的外周血液单核细胞 (PBMC) 进行了RNA测序.
血液样本在基线 (T0),最大运动 (T1) 和运动后四小时 (T2) 收集.
转录组数据被分析,以确定群体和时间点之间的基因表达途径差异.

主要成果:

女性GWI试验对象在促炎途径中表现出放松调节.
与T0.0相比,男性GWI受试者在T1显示IL-12信号和淋巴细胞激活通路的改变,而T0.0则显示IL-12信号和淋巴细胞激活通路的改变.
在压力恢复期间,女性GWI受试者发生了免疫反应和微质激活通路的改变,而男性显示出亡信号的变化.

结论:

在生理压力下的GWI患者中存在显著的性别特异性转录组差异.
这些发现突显了GWI诊断和预后中性别特异性生物标志物的潜力.
针对已识别的转录组路径可以为新的,个性化的GWI疗法铺平道路.

关键词:

海湾战争疾病 (GWI)这就是PBMCs.有关RNA测序的RNA测序在RNA-seqqq.细胞因子信号传递免疫调节失调免疫调节失调这是一种炎症炎症炎症炎症.氧化应激是一种氧化应激.周围血液中的单核细胞.性别差异的性别差异.翻译学翻译学翻译学翻译学

更多相关视频

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

A Rat Methyl-Seq Platform to Identify Epigenetic Changes Associated with Stress Exposure

Published on: October 24, 2018

Measurements of Physiological Stress Responses in C. Elegans

Measurements of Physiological Stress Responses in C. Elegans

Published on: May 21, 2020

相关概念视频

Introduction to Stress and Lifestyle

Introduction to Stress and Lifestyle

Stress is a multifaceted response to events perceived as challenging or threatening, highlighting physical, emotional, cognitive, and behavioral reactions. Physically, stress can lead to fatigue, sleep disruptions, and various health issues such as frequent colds, chest pains, and nausea. Emotionally, it can manifest as anxiety, depression, irritability, and anger triggered by both minor and major life events. Cognitively, it may result in difficulty in concentration, memory, and...

General Transcription Factors

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

Background and Environment Affect Phenotype

Background and Environment Affect Phenotype

Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...