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Updated: May 12, 2025

Analysis of Protein Folding, Transport, and Degradation in Living Cells by Radioactive Pulse Chase
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p.Phe508del-CFTR贩运:通过UPR,UPS和自的蛋白质质量控制视角

Pascal Trouvé1, Claude Férec1

  • 1Univ Brest, Inserm, EFS, UMR 1078, 22 Avenue Camille Desmoulins, F-29200 Brest, France.

International journal of molecular sciences
|May 7, 2025
PubMed
概括

囊性纤维化 (CF) 蛋白质错误折叠可以通过非传统的蛋白质分泌 (UPS) 和未折叠的蛋白质反应 (UPR) 诱导的自进行管理. 调节这些通路可能会增强CFTR蛋白向细胞表面的传递,以获得新的CF疗法.

关键词:
自自是自的过程.传统的蛋白质分泌 (CPS)囊性纤维化 (CF)p.Phe508del-CFTR的使用情况非传统的蛋白质分泌 (UPS)展开的蛋白质反应 (UPR)

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