脏损伤和与代谢功能障碍相关的稳定性肝脏疾病在肥胖患者中
Kellyane Dias Carvalho1, Cláudia Daltro1, Carla Daltro1
1Universidade Federal da Bahia, Faculdade de Medicina da Bahia, Programa de Pós-Graduação em Medicina e Saúde, Salvador, BA, Brasil.
Arquivos de gastroenterologia
|May 7, 2025
概括
在肥胖患者中,年龄是功能下降的主要驱动因素. 肝纤维化进展也显著损害功能,可能表明慢性病.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 肝病学 肝病学是一种肝病学.
- 代谢疾病 代谢疾病
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是全球慢性肝病的主要原因.
- 新出现的证据将MASLD与损伤联系在一起,影响患者的预后.
- 这项研究重点关注肥胖个体中MASLD与脏损伤的相关性.
研究的目的:
- 调查MASLD与肥胖类II和III患者功能之间的临床关联.
- 在这个人群中,确定导致膜过率 (GFR) 降低的关键因素.
主要方法:
- 招募的患者有肥胖症 (BMI>35 kg/m2) 和MASLD.
- 通过组织学或成像诊断MASLD;使用FIB-4和NSF得分评估肝纤维化.
- 使用CKD-EPI方程计算的GFR,将正常GFR定义为≥90和<120mL/min/1.73m2.
主要成果:
- 该研究包括560名肥胖患者和325名患有MASLD的患者 (75.4%的女性,平均年龄为36±10岁).
- 高血压 (41.1%) 和2型糖尿病 (42.8%) 是普遍存在的.
- 51.1%的GFR<114毫升/分钟,其中64%的患者表现为晚期肝纤维化 (FIB-4>0.54).
结论:
- 在患有MASLD的肥胖患者中,年龄是GFR下降的主要因素.
- 淋巴细胞过可能是慢性病早期进展的信号.
- 晚期肝纤维化是这一队列中功能受损的重要因素.
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