肠道微生物群和结肠直肠癌:风险与保护之间的平衡
Vlad Alexandru Ionescu1,2, Camelia Cristina Diaconu1,2,3, Gina Gheorghe1,2
1Faculty of Medicine, University of Medicine and Pharmacy Carol Davila Bucharest, 050474 Bucharest, Romania.
International journal of molecular sciences
|May 7, 2025
概括
肠道微生物群通过促进或阻止其发展来影响结肠直肠癌 (CRC). 了解这种复杂的相互作用是开发基于微生物的CRC疗法和早期检测策略的关键.
科学领域:
- 微生物学和瘤学
- 肠道微生物组研究研究
- 癌症病因学和预防 癌症病因学和预防
背景情况:
- 肠道微生物组包括肠道中微生物的复杂社区.
- 它在结肠直肠癌 (CRC) 的发展中起着双重作用,既是危险因素,也是保护因素.
- 机制包括炎症,氧化应激,免疫逃避和微生物代谢物.
研究的目的:
- 审查肠道微生物群对结直肠癌 (CRC) 发展有所贡献的机制.
- 探索肠道微生物组在CRC病原和保护中的双重作用.
- 突出基于微生物组的干预措施在CRC预防和治疗方面的潜力.
主要方法:
- 对调查肠道微生物组在结直肠癌中的作用的研究进行文献综述.
- 分析包括炎症,氧化应激,免疫逃避和微生物代谢物的机制.
- 特定的致病和保护微生物物种及其相关分子的识别.
主要成果:
- 致病性细菌如 * Fusobacterium nucleatum * * Escherichia coli * (pks +) 和 * Bacteroides fragilis * 通过炎症,氧化应激和DNA损伤促进CRC.
- 这些微生物可以通过影响T细胞群体来抑制抗瘤免疫力.
- 有益的细菌,如 * Lactobacillus * * Bifidobacterium * * 和 * Faecalibacterium prausnitzii * * 产生短链脂肪酸 (SCFA),可以防止CRC.
结论:
- 了解肠道微生物组在CRC中的复杂作用对于开发新的治疗和预防策略至关重要.
- 基于微生物组的干预措施,如益生菌,益生菌和便微生物群移植,对CRC管理有希望.
- 未来的研究应该专注于微生物生物标志物,用于早期CRC检测和个性化微生物向治疗.
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