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禁食血糖波动对2型糖尿病和冠状动脉微循环功能障碍患者左心室功能的影响:一项前性队列研究

Wang Qian^1,2, Xie Lingli¹, Lu Dexue²

¹Department of Endocrinology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, China.

Acta diabetologica

|May 7, 2025

概括

在2型糖尿病 (T2DM) 患者中,患有冠状动脉微循环功能障碍 (CMD) 的高禁食血糖变异性 (FBG-CV) 显著恶化左心室扩张功能. 最佳的FBG-CV低于15%以改善心脏健康.

科学领域:

心脏病学心脏病学
内分泌学在内分泌学.
糖尿病学糖尿病学

背景情况:

2型糖尿病 (T2DM) 是一个日益严重的全球健康问题.
冠状动脉微循环功能障碍 (CMD) 是T2DM患者的常见并发症.
左心室透支功能障碍是心血管不良结果的重要预测因素.

研究的目的:

研究空腹血糖变化 (FBG-CV) 对T2DM患者的左心室功能的影响.
为了确定与扩张功能受损相关的特定FBG-CV值.
评估FBG-CV与左心室透气参数 (如E/e'比) 之间的关系.

主要方法:

一项前性队列研究,涉及290名T2DM患者,持续了18个月.
患者被分为患有 (CMD) 和没有 (非CMD) 冠状动脉微循环功能障碍的组.
计算了空腹血糖变化系数 (FBG-CV),并使用E/e'比率评估左心室功能.

主要成果:

较高的FBG-CV水平与E/e'比率升高显著相关,这表明扩张功能受损.
患有FBG-CV>25%的患者 (CMD1组) 与患有FBG-CV 15%-25% (CMD2) 和<15% (CMD3) 的患者相比,显示出明显更高的E/e'比率.
糖尿病和CMD的过程独立地与E/e'比率升高有关,而口服低血糖剂和胰岛素注射显示出保护作用.

结论:

升高的FBG-CV,特别是超过25%,会对T2DM中心血管疾病患者的左心室透静功能产生不利影响.
在这种患者群体中,保持最佳的FBG-CV低于15%的水平可能对保持透缩功能至关重要.
这些发现凸显了T2DM心血管并发症患者葡萄糖变化管理的重要性.

关键词:

冠状动脉微循环功能障碍禁食血糖的波动禁食血糖的波动左心室的功能是没有的.2型糖尿病是什么? 2型糖尿病是什么?

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