一个分层的下一代风险评估框架,整合了毒动力学和基于NAM的毒动力学:"概念验证"案例研究,使用了铁
Ana Fernandez-Agudo1,2, Jose V Tarazona3
1Spanish National Environmental Health Center, Instituto de Salud Carlos III, Madrid, Spain. ana.fernandez@isciii.es.
Archives of toxicology
|May 7, 2025
概括
新一代风险评估 (NGRA) 的新方法方法 (NAM) 准确评估化学物质的组合暴露. 这种使用毒动力学 (TK) 和毒动力学 (TD) 的分层框架提供了一个监管相关的模型来评估pyrethroids.
科学领域:
- 环境毒理学环境毒理学
- 化学品风险评估 化学品风险评估
- 在的毒理学.
背景情况:
- 由于广泛使用和累积暴露风险,甲酸存在监管挑战.
- 传统的风险评估 (RA) 难以有效评估组合风险.
- 新方法方法 (NAMs) 为改善风险评估提供综合性毒动力学 (TK) 和毒动力学 (TD).
研究的目的:
- 评估一个分层的下一代风险评估 (NGRA) 框架对铁的监管适用性.
- 为了将NGRA与传统RA进行比较,以评估组合化学物质暴露.
- 建立一个强大的模型,用于对甲酸和类似化学品类的监管决策.
主要方法:
- 采用了五层NGRA框架,整合了TC和TD.
- 使用ToxCast数据和体外/体内比较来确定危害和评估影响.
- 暴露边际 (MoE) 分析和TCK建模应用于内部剂量估计.
主要成果:
- 阶层NGRA框架确定了组织特异性途径作为关键风险驱动因素.
- 在体外与体内生物的比较显示了基于间歇度的连贯结果.
- 饮食暴露评估显示的水平低于关注,但非饮食暴露需要进一步评估.
结论:
- 基于TK-NAM的TD的NGRA为风险评估提供了一个细微和监管相关的框架.
- 拟议的方法有效地整合了关于单个铁甲基的信息,并改善了体外-体内比较.
- 这种分层方法为对化学物质联合暴露的监管决策提供了关键的见解.
相关概念视频
01:26Toxic Reactions: Overview
894
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
894
01:36Types of Toxins
1.3K
Humans continually engage with an environment rich in potentially harmful chemicals. These are introduced to our bodies through inhalation, ingestion, or skin contact. These chemicals exist in various forms, such as air and environmental pollutants, agricultural chemicals, organic solvents, and heavy metals.
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
Air pollutants, primarily gases, pose significant threats to respiratory health, leading to conditions like hypoxia, lung cancer, and in extreme cases, death.
Environmental pollutants like...
1.3K