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系统性炎症介导尿和慢性咳风险之间的关系:基于多种统计模型的发现
Jun Wen1, Changfen Wang2, Ranyang Liu3
1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing Medical University, Chongqing, China. wencej@stu.cqmu.edu.cn.
概括
高尿水平与慢性咳风险增加有关. 系统性炎症可能起到作用,表明减少暴露可能降低咳风险.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 有限的研究存在于尿和慢性咳风险之间的关联.
- 尿中的金属是呼吸道疾病的潜在环境风险因素.
研究的目的:
- 调查尿与慢性咳风险之间的关系.
- 探索系统性炎症在这种关联中的调解作用.
- 评估各种统计模型,以根据尿液金属含量预测慢性咳风险.
主要方法:
- 对来自国家健康和营养检查调查 (NHANES) 的2965名参与者的横截面研究.
- 应用加权量子总和 (WQS) 回归,贝叶斯核机器回归 (BKMR),机器学习模型 (随机森林,支持向量机器,决策树,XGBoost),受限立方线 (RCS) 和后勤回归.
- 调解效应模型,以评估系统性炎症的作用.
主要成果:
- 尿中的与慢性咳风险有显著的正相关性 (OR:2.83,95% CI:1.60-4.99).
- WQS回归和BKMR证实了尿道金属混合物与慢性咳之间的积极关联.
- 随机森林模型展示了最好的预测性能 (AUC=0.69),确定尿,,,,和作为关键预测因素.
- 系统性炎症标志物 (淋巴细胞,系统性免疫炎症指数) 部分介导了与慢性咳的关系.
结论:
- 尿路含量升高与慢性咳风险增加有关.
- 系统性炎症部分介导尿和慢性咳之间的联系.
- 减少暴露可能是缓解慢性咳风险的策略.
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