在B细胞消耗单一治疗后,对SARS-COV-2的免疫记忆的延迟但成功的发展
Nicolas Graf1,2, Joseph Bayerl3, Barbara Schmidt4
1Medical Department II, Section Oncology, Donau-Isar-Klinikum Deggendorf, Deggendorf, Germany. nicolasgraf@gmx.de.
Infection
|May 7, 2025
概括
接受CD20导向治疗的患者在单一治疗和至少6个月后治疗时,对第三种SARS-COV-2疫苗的抗体反应有所改善. 在这些患者中,也可能出现延迟的免疫反应.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 在瘤学瘤学.
背景情况:
- 接收CD20导向治疗的患者在接种两次疫苗后,往往对SARS-COV-2的中和抗体标位不足.
- 这项研究调查了这种患者群体中额外接种疫苗的影响.
研究的目的:
- 评估第三次和第四次基于mRNA的SARS-COV-2疫苗接种在接受CD20导向治疗的患者中的有效性.
- 为了确定足够的幽默免疫反应的预测因素.
主要方法:
- 一项前性观察性研究包括接受单克隆CD20抗体 (mCD20Ab) 的患者.
- 在第三次接种疫苗之前和之后测量了SARS-COV-2 IgG标位.
- 没有充分反应的患者进行了第四次接种疫苗. 分析了耐受性和影响因素.
主要成果:
- 第三次接种疫苗耐受性良好,显示IgG标位显著增加,但临床上没有相关的血清转化率.
- 65岁以上的患者和6个多月前接受mCD20Ab治疗的患者受益.
- 用mCD20Ab单一治疗与立即或延迟反应相关,而组合治疗患者没有反应.
结论:
- 在最后一次mCD20Ab注射和mCD20Ab单疗后至少6个月的间隔有利于对第三种SARS-COV-2疫苗产生幽默反应.
- 延迟的免疫反应是可能的,需要在以后的时间点进行调查.
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