老年营养风险指数作为肝硬化整体存活率的预测指标:一项回顾性队列研究
Chun-Yan Sun1, Yu-Ning Wang2, Hong-Fei Zhan1
1Department of Gastroenterology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, 200120, China.
Current medical science
|May 7, 2025
概括
较低的老年营养风险指数 (GNRI) 评分表明肝硬化患者的并发症风险更高,生存率更差. 全国营养指数是评估营养状况和预测这一群体结果的宝贵工具.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 营养科学 营养科学
- 老年病的医生 老年病的医生
背景情况:
- 营养状况不佳与肝硬化患者的并发症和死亡率增加有关.
- 老年营养风险指数 (GNRI) 是营养评估的一个常见工具.
研究的目的:
- 评估GNRI对肝硬化患者结局的预测值.
- 确定GNRI与肝硬化患者的整体存活率 (OS) 和并发症之间的关联.
主要方法:
- 对420名肝硬化患者 (2013-2017) 的回顾性研究.
- 患者分为高 (≥92) 和低 (<92) 的GNRI组.
- 卡普兰-梅尔,考克斯的比例危险,以及用于生存和关联分析的受限制立方脊柱模型.
- 开发了一个名ogram来预测OS.
主要成果:
- 较低的GNRI得分与较高的死亡率相关 (18.73%对5.23%).
- GNRI独立预测了OS (HR=0.958,P=0.007) 并与,自发细菌性腹膜炎,肝脑病 (HE) 和肝综合征 (HRS) 有关.
- 结合GNRI和其他因素的诺米图表实现了良好的预测准确性 (C统计学0.83在1年,0.80在2年).
结论:
- 较低的GNRI得分与肝硬化患者的并发症增加和整体存活率降低有关.
- 该GNRI作为一个有用的指标营养状况和预后在肝硬化患者.
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