自由三甲氨酸和生物衰老之间的年龄特异关系
Chang Liu1, Xue-Chun Han1,2, Lin Hua3
1Department of Endocrinology, Beijing Tongren Hospital, Capital Medical University, 1 Dong Jiao Min Xiang, Beijing, 100730, China.
Hormones (Athens, Greece)
|May 7, 2025
概括
甲状腺激素水平显示了与生物衰老的年龄相关的联系. 较低的自由三甲状腺素 (FT3) 可能表明老年人衰老加速,而较高的FT3与年轻人更快的衰老有关.
科学领域:
- 内分泌学 在内分泌学.
- 老年学是指老年学的学科.
- 生物标志物 生物标志物
背景情况:
- 甲状腺激素,特别是自由三甲状腺素 (FT3),在新陈代谢和衰老中起着至关重要的作用.
- 现型年龄加速 (PhenoAgeAccel) 是衡量生物衰老的尺度,它偏离时间学年龄.
- 了解甲状腺功能和PhenoAgeAccel之间的关系对于评估健康span很重要.
研究的目的:
- 在不同年龄组中调查FT3水平和PhenoAgeAccel之间的关联.
- 为了确定这种关联是否因年龄和性别而异.
- 为了评估FT3对PhenoAgeAccel的预测性能.
主要方法:
- 分析了来自NHANES 1999-2018的7,564名参与者.
- 定义PhenoAgeAccel的定义是表型年龄超过时间年龄.
- 权重多变量后勤回归和受限立方线分析来评估FT3和PhenoAgeAccel的关系.
主要成果:
- 在60岁以下的个人中,较高的FT3水平与增加的PhenoAgeAccel风险有关 (OR: 1.316).
- 高水平的FT3与60岁及以上个体的PhenoAgeAccel风险降低有关 (OR:0.485).
- 这些关联在男性中更明显,并通过ROC曲线显示了公平的预测性能.
结论:
- 在FT3水平和生物衰老加速之间存在一种新的,年龄相关的关联.
- 较低的FT3可能是老年人加速衰老的生物标志物.
- 甲状腺功能与全身健康的复杂关系在整个寿命中各不相同.
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