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Updated: May 12, 2025

A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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由双NR4A1/2干抑制的瘤原核受体4A (NR4A) 调节基因β1-整基因和G9a的表达

Lei Zhang1, Victoria Gatlin2,3, Shreyan Gupta2,3

  • 1Department of Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX 77843, USA.

International journal of molecular sciences
|May 7, 2025
PubMed
概括

DIM-3,5化合物向核受体4A1 (NR4A1) 和NR4A2,作为逆agonists阻止与癌症相关的基因表达. 这些化合物降低基因促进者的关键因素,影响结肠癌细胞中常见的通路.

关键词:
在NR4A1中,在NR4A2中,具有亲瘤原性的作用.可准的可准的目标.

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