阿迪波基尼特激素及其受体调节Tribolium castaneum中的运动行为
Rui-Han Lu1, Xu-Dong Pang1, Shuang-Qin Wen1
1Guizhou Provincial Key Laboratory for Agricultural Pest Management of the Mountainous Region, Institute of Entomology, College of Agriculture, Guizhou University, Guiyang 550025, China.
Insects
|May 7, 2025
概括
阿迪波动因子激素 (AKH) 和它们的受体 (AKHR) 调节红面粉甲虫的运动. 沉默AKH/AKHR显著减少了甲虫的运动,揭示了它们在昆虫活动中的关键作用.
科学领域:
- 神经内分泌学神经内分泌学
- 昆虫生理学 昆虫生理学
- 分子生物学分子生物学
背景情况:
- 运动行为调节对于昆虫的生存和生命活动至关重要.
- 神经是包括运动在内的生理过程的关键调节剂.
- 阿迪波基尼特激素 (AKH) 是一种已知的昆虫神经激素,参与脂质调动.
研究的目的:
- 调查脂动力激素 (AKH1和AKH2) 和它们的受体 (AKHR) 在红色面粉甲虫 (Tribolium castaneum) 中调节运动中的功能作用.
- 阐明在昆虫运动控制中的AKH/AKHR信号的分子机制.
主要方法:
- 功能性记者测试以评估AKH对AKH的激活.
- 基因表达分析以确定AKH和AKHR转录的局部.
- 通过RNA干扰 (RNAi),使AKH和AKHR基因沉默,并观察运动的影响.
主要成果:
- AKHR是由两种成熟的AKH从 *T.castaneum* 激活,具有纳米 EC50 值.
- 在大脑中检测到AKH1和AKH2转录,而AKHR表达在脂肪体和尸体中被发现.
- 沉默AKH或AKHR导致T.castaneum*运动距离和持续时间显著减少.
结论:
- AKH/AKHR的信号传输在 *Tribolium castaneum* 中的运动运动活动中起着重要的调节作用.
- 这些发现促进了对控制经济重要昆虫物种运动的分子机制的理解.
相关概念视频
01:30Regulation of Food Intake
155
Short-term regulation of food intake primarily involves neural signals from the gastrointestinal (GI) tract, blood nutrient levels, and GI tract hormones. Communication between the gut and brain via vagal nerve fibers plays a significant role in evaluating the contents of the gut. Clinical studies have shown that protein ingestion produces a more prolonged response in these nerve fibers compared to an equivalent amount of glucose. Additionally, the activation of stretch receptors caused by GI...
155
01:19Regulation of Metabolism
9.2K
Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
9.2K
01:26Secondary Messengers in Hormone Action
1.9K
Water-soluble hormones cannot cross the plasma membrane, so they rely on protein receptors that span the membrane to trigger intracellular signaling pathways. These pathways then activate second messengers inside the cell, including cAMP or calcium ions.
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
Many hormones bind to transmembrane G protein-coupled receptors that connect to regulatory G proteins. These G proteins can then activate enzymes such as adenylyl cyclase or phospholipase C. Adenylyl cyclase converts ATP to cAMP, activating...
1.9K
01:28Insulin: The Receptor and Signaling Pathways
1.0K
Insulin action is mediated through a receptor tyrosine kinase, akin to the IGF-1 receptor. The number of receptors per cell varies significantly, from 40 on erythrocytes to 300,000 on adipocytes and hepatocytes. The insulin receptor consists of linked α/β subunit dimers, forming a heterotetramer glycoprotein with two extracellular α subunits and two β subunits spanning the membrane. The α subunits inhibit the inherent tyrosine kinase activity of the β subunits, but...
1.0K
01:27Transducer Mechanism: Enzyme-Linked Receptors
2.3K
Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Major types that are helpful drug targets include:
2.3K
01:25cAMP-dependent Protein Kinase Pathways
6.0K
Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
6.0K