德尔菲小组为发展转移性皮肤性克朗氏病的诊断标准:一个共识声明
Joseph Ebriani1,2, Karla Santiago-Soltero1,3, Ellen E Anshelevich1,4
1Department of Dermatology, Brigham & Women's Hospital, Boston, Massachusetts.
这项研究建立了第一个诊断转移性皮肤克朗病 (MCD) 的诊断标准,这是一个罕见的疾病. 这些由专家定义的标准将有助于诊断,研究和开发MCD的结果措施.
科学领域:
- 皮肤病学 皮肤病学
- 胃肠病学 胃肠病学
- 罕见疾病 罕见疾病
背景情况:
- 转移性皮肤克罗恩病 (MCD) 是一种罕见的疾病,缺乏确定的诊断标准.
- 由于没有正式的标准,这阻碍了MCD的临床护理,研究和治疗开发.
研究的目的:
- 定义一种基于共识的诊断标准,用于转移性皮肤性克罗恩病 (MCD).
主要方法:
- 一个由19名MCD和相关疾病专家组成的小组参加了连续调查过程.
- 关于被认为足够,必要或高度暗示MCD诊断的临床和组织学发现,寻求共识.
- 开发了口腔,生殖器和其他MCD亚型的标准.
主要成果:
- 在诊断标准上达成共识,包括生殖器/其他MCD的2个主要标准和5个次要标准,以及口腔MCD的5个次要标准.
- 专家们一致认为,虽然某些组织病理学发现是有意义的,但它们对于MCD诊断并不必要.
- 多发性疾病可以表现为口腔疾病,生殖器疾病,或很少,在其他地方.
结论:
- 已建立的MCD诊断标准代表了临床实践和研究的重大进展.
- 这些标准将促进诊断代码的验证,为翻译研究标准化疾病实体,并使得结果测量的开发成为可能.
- 这种共识为改进诊断和未来治疗转移性皮肤性克罗恩病的治疗策略提供了基础.
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