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Updated: May 12, 2025

Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities
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Assessment of Morphine-induced Hyperalgesia and Analgesic Tolerance in Mice Using Thermal and Mechanical Nociceptive Modalities

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2016年CDC的阿片类药物指南以及癌症老年人的止痛药处方模式

Rebecca Rodin1, Lihua Li1,2, Karen McKendrick1,2

  • 1Brookdale Department of Geriatrics and Palliative Medicine, Icahn School of Medicine at Mount Sinai, New York, New York.

JAMA network open
|May 7, 2025
PubMed
概括

2016年CDC的阿片类药物指南导致老年癌症患者的阿片类药物处方减少. 这种转变导致了对特拉马多尔和 gabapentinoids 的使用增加,这些药物在治疗癌症疼痛方面可能不那么安全和有效.

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Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
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