抗微生物耐药性和犬类细菌性皮肤感染的危险因素
Qian Wang1, Siyu Chen1,2, Shizhen Ma3,4
1College of Veterinary Medicine, China Agricultural University, Beijing 100193, China.
Pathogens (Basel, Switzerland)
|May 7, 2025
概括
狗的细菌性皮肤感染很常见,在关键病原体如Staphylococcus pseudintermedius中观察到抗菌素耐药性增加. 有效的管理需要严格的医院消毒和监测抗生素耐药性模式,以打击MRSP.
科学领域:
- 兽医皮肤病学 兽医皮肤病学
- 细菌学 细菌学是一门学科.
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 细菌性皮肤感染在狗中很普遍,通常是其他疾病的次要原因.
- 未经治疗的感染可能导致复发性疾病和抗菌素耐药性的发展,包括耐甲西林的 Staphylococcus pseudintermedius (MRSP).
研究的目的:
- 分析来自狗皮肤感染的细菌分离物,并评估抗菌素敏感性.
- 为了确定与MRSP感染相关的风险因素.
- 为了研究细菌菌株的遗传关系.
主要方法:
- 对896个犬类细菌性皮肤感染样本 (2018-2022) 的分析.
- 使用MALDI-TOF和16S rRNA基因测序进行细菌鉴定.
- 通过微稀释进行抗微生物敏感性测试.
- 多变量逻辑回归和核心基因组SNP分析.
主要成果:
- 最常见的分离物是Staphylococcus pseudintermedius,Pseudomonas aeruginosa和大肠杆菌. 这些分离物是最常见的分离物.
- 观察到耐药性增加:S. pseudintermedius的佛罗芬尼科尔耐药性 (9.1%至20.0%) 和大肠杆菌的塞夫特里亚耐药性 (30.0%至72.7%).
- 皮肤炎和耳炎是最常见的感染类型.
- 与入侵史和长期疾病持续时间相关的MRSP感染.
- 在多只狗中发现了相同的S. pseudintermedius菌株,其中一个菌株迅速发展出抗 gentamicin 的抵抗力.
结论:
- 狗的细菌性皮肤感染,特别是MRSP的有效管理需要加强消毒,控制感染持续时间,预防复发,并持续监测抗生素耐药性.
- 了解菌株动态和耐药性发展对于治疗策略至关重要.
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