接种COVID-19疫苗可以保护骨肌肉免受与他类药物相关的副作用的影响
Daria Schetz1, Jacek Sein Anand2,3, Karolina Kuźbicka1
1Department of Pharmacology, Faculty of Medicine, Medical University of Gdańsk, 80-210 Gdańsk, Poland.
Vaccines
|May 7, 2025
概括
在COVID-19患者中使用静止剂与较高的肌肉疼痛和肌酸激酶 (CK) 水平有关. 完全接种COVID-19疫苗可能会减少这些肌肉症状,特别是在老年人和女性中.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 药理学 药理学是指药理学的学科.
背景情况:
- COVID-19 (2019年冠状病毒疾病) 对全球卫生系统产生了重大影响.
- 疫苗对于减轻COVID-19的影响至关重要.
- 用于失脂症的他类药物可以引起与肌肉相关的副作用,可能会因COVID-19而恶化.
研究的目的:
- 评估COVID-19患者使用他类药物和肌肉症状 (疼痛,肌酸酶水平) 之间的关联.
- 调查COVID-19疫苗接种状态对这些肌肉相关症状的影响.
主要方法:
- 在147名具有症状的COVID-19患者 (74名他类药物使用者,73名非使用者) 的观察性研究中.
- 通过数值评分表 (NRS) 评估肌肉疼痛和测量肌酸酶 (CK) 水平.
- 记录疫苗接种情况 (未接种疫苗,一剂,两剂Pfizer-BioNTech) 和分析的人口因素.
主要成果:
- 达丁类药物使用者表现出较高的CK水平和略高的严重狂犬病发病率.
- 服用他类药物的老年人 (≥65) 显示CK水平显著升高;男性的CK值更高.
- 与未接种疫苗的患者相比,完全接种疫苗的患者报告肌肉疼痛较少,CK值较低.
结论:
- 在COVID-19患者中,他类药物的使用与肌肉疼痛增加和CK水平升高有关.
- 老年人和女性可能更容易受到严重的肌肉并发症的影响.
- 完全接种COVID-19疫苗似乎可以减轻与他类药物相关的肌肉症状.
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