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Updated: May 12, 2025
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薄荷醇和基于甲醇的天然深性溶剂的物理化学和生物特性
Martina Bagović Kolić1, Martina Železnjak1, Ksenija Markov2
1Laboratory for Cell Technology, Application and Biotransformations, Department of Biochemical Engineering, Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, Croatia.
Molecules (Basel, Switzerland)
|May 7, 2025
概括
七种以烯为基础的疏水性深溶剂 (hDES) 显示出对工业应用的前景. 基于硫醇的hDES表现出优异的抗氧化和抗菌活性,没有观察到细胞毒性,表明它们作为更安全的溶剂替代品的潜力.
科学领域:
- 绿色化学 绿色化学
- 超分子化学 超分子化学
- 材料科学 材料科学 材料科学
背景情况:
- 疏水性深度浸溶剂 (hDES) 正在成为传统溶剂的可持续替代品.
- 它们的物理化学和生物性质的表征对于工业采用至关重要.
- 基于烯的hDES由于其可调节性质,为各种应用提供了潜力.
研究的目的:
- 针对工业适用性和环境影响,对七种hDES进行表征.
- 评估它们的物理化学特性,抗氧化能力,抗菌活性和细胞兼容性.
- 通过植物毒性和植物抗氧化剂测定来评估环境影响.
主要方法:
- 确定物理化学性质 (极性,密度,粘度).
- 使用氧基吸收能力 (ORAC) 评估抗氧化能力.
- 通过最小抑制度 (MIC) 对细菌和酵母菌株进行抗菌活性评估.
- 在人体细胞系上进行体外细胞相容性测试 (HaCaT,CaCo-2,HeLa).
- 在小麦上进行植物毒性和体外抗氧化分析.
主要成果:
- 与基于薄荷醇的hDES相比,基于薄荷醇的hDES显示出更高的极性和密度,以及较低的粘度.
- 基于蒂摩尔的hDES,特别是含有库马林的hDES,显示出显著的抗氧化潜力 (最高的ORAC值).
- 所有测试的hDES都显示出对测试菌株的抗微生物和抗真菌活性.
- 在高达1000毫克L-1.1的人类细胞系上,没有观察到HDES的细胞毒性作用.
- 选择的hDES显示轻微的植物毒性,但调节了植物对氧化应激的防御机制.
结论:
- 基于烯的hDESs,特别是基于硫醇的变种,具有有利的物理化学和生物特性.
- 这些hDES显示出在食品,化品和制药行业中作为安全有效的替代溶剂的潜力.
- 对它们对环境的影响进行进一步的研究是有必要的,尽管初步发现表明植物毒性中等.
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