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黄金纳米颗粒的表面修改影响明显的脂质代谢

Xinyu Ding¹, Shanshan Liang^1,2, Tingfeng Zhang^1,2

¹CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China.

Molecules (Basel, Switzerland)

|May 7, 2025

概括

黄金纳米颗粒 (GNPs) 与素或聚乙胺涂层改变了小鼠的关键代谢途径. 类胆化合物可能表明功能化GNP的生物效应不同.

科学领域:

生物医学是生物医学.
纳米技术纳米技术
毒理学毒理学毒理学

背景情况:

黄金纳米粒子 (GNPs) 由于其独特的特性,在纳米医学中被广泛使用.
对GNP的表面修改对于提高其安全性和有效性至关重要.
了解不同GNP表面化学的生物影响至关重要.

研究的目的:

在小鼠模型中研究三种不同的GNP表面修饰 (聚乙烯糖醇,奇托,聚乙烯) 的生物效应.
阐明对肝组织的转录和代谢作用机制.
为了确定不同生物效应的潜在生物标志物.

主要方法:

用小鼠模型来研究功能化黄金纳米粒子的影响.
对肝脏组织进行了转录和代谢分析.
应用了统计方法,包括错误发现率 (FDR),以识别显著的途径变化.

主要成果:

聚乙烯糖醇修饰的GNP (PEG-GNP) 对主要代谢途径没有显著影响.
基托桑修饰的GNP (CS-GNP) 显著影响了视网醇,阿拉基酸,酸和葡萄糖脂代谢 (FDR <0.05).
聚乙烯胺基基基因基因基因基因 (PEI-GNPs) 显著影响了视网醇,阿拉基酸,酸和脂代谢 (FDR < 0.05).

结论:

功能化的GNP对肝脏新陈代谢有不同的生物学影响.
类胆化合物被确定为这些差异效应的潜在生物标志物.
这项研究为评估功能化GNP在纳米医学应用中的生物安全性提供了关键数据.

关键词:

金纳米颗粒的金子纳米颗粒代谢生物组的代谢生物组表面功能化的功能化.转录组学转录组学是指转录组学.

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