三糖-葡萄糖指数与不孕症人口中全因和心血管死亡率之间的关联
Yuhan Wang1, Yishu Tian2, Feifei Zhou1
1Department of Reproductive Endocrinology, Center for Reproductive Medicine, Zhejiang Provincial People's Hospital (Affiliated People's Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, China.
甘油三糖 (TyG) 指数与不孕妇女因任何原因死亡的风险更高有关. 然而,这项研究没有发现TyG指数与心血管疾病死亡率在该人群之间存在关联.
科学领域:
- 内分泌学 在内分泌学.
- 心血管健康 心血管健康
- 生殖健康 生殖健康
背景情况:
- 三甘油糖指数 (TyG) 与不孕妇女的死亡结果之间的关联尚未得到充分证实.
- 甘油三糖 (TyG) 指数正在成为胰岛素抵抗和代谢功能障碍的标志物.
研究的目的:
- 调查甘油三糖指数 (TyG) 与不孕妇女所有原因和心血管死亡率之间的关系.
- 利用一个大型的国家队列来提供关于这种关联的强有力的证据.
主要方法:
- 分析了十个国家健康和营养检查调查 (NHANES) 数据集,涵盖了近20年的时间.
- 将NHANES数据与国家死亡指数结合起来,以对死亡率进行跟踪.
- 采用多变量Cox比例危险回归模型来评估TyG指数水平与死亡率之间的关联.
主要成果:
- 在高TyG指数水平和不孕妇女全因死亡率之间观察到显著的积极关联.
- 在调整了多种混因素 (包括年龄,种族,BMI和并发症) 之后,这种关联仍然存在.
- 在这个队列中,TyG指数和心血管死亡率之间没有发现显著的关联.
结论:
- 高水平的甘油三糖指数 (TyG) 与不孕妇女全因死亡率的增加有关.
- 泰格指数可以作为这个人群总生存率的潜在预后标志物.
- 需要进一步的研究来探索这种关联及其临床影响背后的机制.
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