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Updated: May 12, 2025

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在肺腺癌中基于基因表达的预后标记物的基因表达识别

Annette Salomonsson1, Daniel Ehinger1,2, Mats Jönsson1

  • 1Department of Clinical Sciences Lund, Division of Oncology, Lund University, Lund, Sweden.

PloS one
|May 7, 2025
PubMed
概括

这项研究使用基因表达识别了19个与肺腺癌整体存活相关的基因. 虽然选择的标记物 (Ki67,MCM4,TYMS) 缺乏通过IHC进行独立预后的能力,但该战略对发现临床生物标记物充满希望.

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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