通过结合双列并行HPLC指纹和UPLC-Q-TOF-MS/MS的双列并行组合,进行Sarcandrae草药的多组件表征和质量评估策略
Zhijian Zhong1,2, Pan Deng1,2, Xiaorong Luo1
1Jiangzhong Pharmaceutical Co., Ltd., Nanchang 330100, China.
Molecules (Basel, Switzerland)
|May 7, 2025
概括
这项研究使用UPLC-Q-TOF-MS/MS指纹进行了Sarcandrae草的质量控制. 化学分析成功地将Sarcandrae草药从各种来源区分开来.
科学领域:
- 植物化学 植物化学
- 分析化学 分析化学
- 药理学是指药理学,它是指药理学.
背景情况:
- 萨尔坎德拉 (Sarcandrae herba) 是一种具有不同品质的传统药用植物.
- 建立有效的质量控制方法对于Sarcandrae herba.至关重要.
- 化学指纹提供了一种全面的质量评估方法.
研究的目的:
- 开发一种快速有效的方法,用于Sarcandrae草的整体质量控制.
- 来自不同来源的Sarcandrae草药的化学组成的特征.
- 为了确定Sarcandrae草的化学指纹.
主要方法:
- 采用双列并列模式液态染色学与高分辨率质谱学 (UPLC-Q-TOF-MS/MS) 结合使用.
- 对来自24个不同来源的Sarcandrae草本样本建立了化学指纹.
- 使用化学测量方法,包括相似性评估,主要成分分析和集群分析.
主要成果:
- 在Sarcandrae草药中首次发现了9种常见的化学成分.
- 总共有92种化合物被使用液体质谱学识别出来.
- 已建立的指纹和质谱分析有效地区分了Sarcandrae草的起源.
结论:
- 基于UPLC-Q-TOF-MS/MS的指纹采集方法为Sarcandrae草的质量控制提供了可靠的基础.
- 这项研究成功地描述了来自不同来源的Sarcandrae草的化学特征.
- 这种方法使得Sarcandrae草根可以根据其地理来源和化学成分进行区分.
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