1,2,4-氧化衍生物的合成和抗真菌活性
Lili Yu1,2,3,4, Kuan Yang1,2,3,4, Lin Yao1,2,3,4
1Xi'an Key Laboratory of Multi Synergistic Antihypertensive Innovative Drug Development, Xi'an Medical University, Xi'an 710021, China.
Molecules (Basel, Switzerland)
|May 7, 2025
概括
新的1,2,4-oxadiazole衍生物被合成为潜在的糖酸脱酶 (SDH) 抑制剂. 化合物4f和4q对关键植物病原体表现出显著的抗真菌活性,而化合物4f的性能优于商业真菌杀菌剂.
科学领域:
- 药用化学 医学化学
- 农业科学 农业科学
- 分子生物学分子生物学
背景情况:
- 植物病原菌在全球范围内造成重大作物损失.
- 酸脱酶 (SDH) 是真菌呼吸中的关键酶,也是抗真菌剂的目标.
- 开发新的SDH抑制剂对于有效的疾病管理至关重要.
研究的目的:
- 设计和合成新型的1,2,4-oxadiazole衍生物,其中包括酸或酸部分.
- 评估这些衍生物对重要的植物病原菌的体外和体内抗真菌活性.
- 通过分子对接模拟来研究潜在的作用机制.
主要方法:
- 1,2,4-oxadiazole衍生物的合成.
- 使用NMR (H,C) 和ESI-MS. 的结构特征.
- 通过细胞生长抑制进行体外抗真菌查.
- 在体内对鱼进行抗真菌测试.
- 对抗酸脱酶 (SDH) 的分子对接模拟.
主要成果:
- 化合物4f和4q对*Rhizoctonia solani*,*Fusarium graminearum*,*Exserohilum turcicum*,*Botrytis cinerea*和*Colletotrichum capsica*表现出显著的广泛的抗真菌活性.
- 与carbendazim.com相比,4f化合物对 *Exserohilum turcicum* 的疗效更高.
- 这两种化合物都在体内表现出对*Colletotrichum capsica*的抗真菌作用.
- 分子对接揭示了4f和4q化合物通过键和疏水性相互作用与SDH相互作用,阐明了它们的抑制机制.
结论:
- 合成的1,2,4-oxadiazole衍生物是新型抗真菌剂的有希望的候选者.
- 化合物4f和4q表现出强大且广泛的抗真菌活性,需要进一步研究.
- 该研究提供了对这些SDH抑制剂的结构-活性关系和作用机制的见解.
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