Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Whole Body Regeneration01:33

Whole Body Regeneration

3.3K
Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential;...
3.3K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Pre-vaccination immune signatures of children with inborn errors of immunity associate with COVID-19 vaccine response.

Human vaccines & immunotherapeutics·2026
Same author

Multimodal single cell analyses reveal gene networks of planarian stem cell differentiation.

Nature communications·2025
Same author

The Biodiversity Cell Atlas: mapping the tree of life at cellular resolution.

Nature·2025
Same author

The Hydractinia cell atlas reveals cellular and molecular principles of cnidarian coloniality.

Nature communications·2025
Same author

Hemichordate cis-regulatory genomics and the gene expression dynamics of deuterostomes.

Nature ecology & evolution·2024
Same author

Annelid adult cell type diversity and their pluripotent cellular origins.

Nature communications·2024

相关实验视频

Updated: May 12, 2025

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

29.7K

通过单细胞转录组学对平面体细胞类型的异构测量.

Elena Emili1, Alberto Pérez-Posada1,2,3, Virginia Vanni1,2,3

  • 1Department of Biological and Medical Sciences, Oxford Brookes University, Oxford, UK.

Science advances
|May 7, 2025
PubMed
概括

这项研究揭示了细胞比例如何随着平面动物体型的变化而变化,使用单细胞RNA测序. 肠道基底细胞是尺寸适应的关键,突出了细胞类型全量学.

更多相关视频

Isolation and Transcriptome Analysis of Plant Cell Types
08:53

Isolation and Transcriptome Analysis of Plant Cell Types

Published on: April 7, 2023

1.3K
High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology
08:19

High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology

Published on: May 28, 2020

7.8K

相关实验视频

Last Updated: May 12, 2025

Transcriptome Analysis of Single Cells
07:27

Transcriptome Analysis of Single Cells

Published on: April 25, 2011

29.7K
Isolation and Transcriptome Analysis of Plant Cell Types
08:53

Isolation and Transcriptome Analysis of Plant Cell Types

Published on: April 7, 2023

1.3K
High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology
08:19

High-Throughput Quantitative RT-PCR in Single and Bulk C. elegans Samples Using Nanofluidic Technology

Published on: May 28, 2020

7.8K

科学领域:

  • 发展生物学 发展生物学
  • 生态生态学 生态生态学
  • 基因组学就是基因组学.

背景情况:

  • 立体测量学研究了人体尺寸和生物特征之间的关系.
  • 细胞类型全量计,研究细胞比例如何随身体大小而变化,尚未得到充分研究.
  • 单细胞RNA测序 (scRNA-seq) 为研究细胞异质性提供了新的工具.

研究的目的:

  • 用scRNA-seq.来研究平面生物中的细胞类型全量学.
  • 为了确定细胞类型的比例如何与生物体大小不同.
  • 了解背后的大小依赖细胞变化的分子机制.

主要方法:

  • 利用scRNA-seq分析不同大小的平面体中的细胞组成.
  • 通过比较不同细胞类型和体型的基因表达特征.
  • 确定了与身体尺寸变化相关的受调节基因模块.

主要成果:

  • 平面生物保持相同的基本细胞类型,但根据身体大小改变它们的比例.
  • 肠道基底细胞显示出与大小成比例的最显著的变化,这表明它们有储能作用.
  • 特定的基因模块被确定为针对不同细胞类型的身体大小而受到调节.

结论:

  • 细胞类型的全量计是生物体大小调节的一个重要因素.
  • 平面肠道基底细胞在适应身体尺寸变化方面发挥着至关重要的作用.
  • scRNA-seq是一种强大的技术,用于剖析细胞类型全量学及其分子基础.